Born in Chicago, Illinois, Prexy Nesbitt was educated at Antioch College, Yellow Springs, Ohio. He went on to attend the University of Dar Es Salaam, Tanzania; Northwestern University, Illinois; and Columbia University, New York.

An activist and an educator, he has been highly active in labor, human rights, and equality movements. In 1970 he worked for the American Committee on Africa where he organized anti- apartheid groups in the Midwest. In 1978 he was named director of the Africa Project at the Institute of Policy Studies, Washington, D.C. and in 1979, became the program director and research secretary at the World Council of Churches, Geneva, Switzerland.

In 1986, Nesbitt returned to Chicago to continue his work as a labor organizer. In 1986, then Chicago mayor Harold Washington named him as a special aide and in 1987, the Mozambique government appointed him consultant to represent the country and its interests in the United States, Canada, and Europe, remaining in the post until 1992. In 1993, he served as the senior program officer with the Program on Peace and International Cooperation with the MacArthur Foundation, a position he held until 1996.

While working with the foundation, Nesbitt also taught in several different institutions: Francis W. Parker High School; the Associated Colleges of the Midwest; and Columbia College Chicago, where he continues to teach African and American history courses and has lectured and organized conferences throughout the United States and abroad.

In 2001, he was named the South African representative for the American Center for International Labor Solidarity, Johannesburg, South Africa as well as serving as the interim director for the American Friends Service Committee Africa Program. In 2003, he worked as the Senior Multiculturalism and Diversity Specialist at the Chicago Teachers Center, Northeastern Illinois University.

He has also served as consultant to the Francis W. Parker School, Chicago, and the East Educational Collaborative, Washington, D.C., and the University of Chicago Laboratory Schools and has also published a book and written articles that appeared in more than twenty international journals.

During his career, Nesbitt has traveled extensively, including numerous trips to South Africa, several of which were taken in secret so as to not alert members of the apartheid government. Prexy Nesbitt's oral history interview conducted in 2009 at Columbia College Chicago offers more about his work as an activist and educator.